Magnetic Mixers Uses in Biotechnology

What is the working principle of magnetic mixer?

Revolutionising the biotechnology sector, magnetic coupled mixers operate on the principle of a rotating magnetic field, inducing the rapid spinning of a stir bar immersed in liquid for efficient stirring. This magnetic field can be generated by either a rotating magnet or stationary electromagnets beneath the liquid-containing vessel. In the pharmaceutical and biotech industries, these mixers are indispensable for their reliability, ease of maintenance, and minimal risk of product contamination. Steridose, a pioneer in the biopharmaceutical realm, introduced the Sterimixer over 30 years ago, marking a significant application and fine-tuning of this technology for biotech purposes. Configurable to optimise flow or shear, the Sterimixer contributes to higher yields and more efficient processes. These mixers find diverse applications in biotechnology, including buffer/media preparation, product storage, filtration, addition of easy-dissolving solids, blending of miscibles, and mixing shear-sensitive and abrasive materials, showcasing their pivotal role in improving mixing efficiency and product yield while minimising contamination risks. Magnetic coupled mixers are indeed revolutionising biotechnology by elevating mixing processes to new levels of efficiency and reliability.

Mixers Used in Biotechnology

Magnetic mixers find versatile applications across various domains within the biotechnology sector, demonstrating their efficacy in pharmaceutical formulations, microfluidic devices, and large-scale stirred vessels. In the pharmaceutical and biotech industries, these mixers are indispensable, tailored to meet the stringent requirements of liquid-based pharmaceutical formulations, ensuring compliance with standards for cleanability, drainability, bioburden control, low-shear performance, and comprehensive documentation. Their adaptability and precision make them a reliable choice in microfluidic devices, where they contribute to micro reactors, concentration gradient generators, micro-heat exchangers, and lab-on-a-chip devices. Magnetic mixers exhibit resilience to external factors such as surface charges, pH variations, and ion concentrations while avoiding the introduction of excess heat. These mixers seamlessly integrate into large-scale stirred vessels, offering advantages such as easy installation, reduced power requirements, and suitability for applications in viscous fermentations. The widespread use of magnetic mixers across these diverse applications underscores their indispensability in driving efficiency and precision in various biotechnological processes.

Exploring the Unique Features of Magnetic Mixers for Biotechnological Processes

In biotechnological processes, magnetic mixers stand out with a distinctive set of features that cater to the industry’s specific demands. These mixers offer unparalleled precision and control, accommodating a broad range of speeds to ensure meticulous control over the mixing process, a critical factor in biotechnology where slight variations can significantly impact outcomes. The inclusion of a specially designed four-wing impeller enhances pumping efficiency, safeguarding product integrity through efficient mixing. Full drainability, a vital attribute in biotechnological processes, is assured, leaving no residues behind. Magnetic mixers also contribute to cost efficiency with longer-lasting, easy-to-replace bearings, translating into reduced maintenance costs. Designed to meet the rigorous standards of liquid-based pharmaceutical formulations, these mixers prioritize hygiene, validated through criteria like cleanability, drainability, bioburden control, and low-shear performance. The provision of thorough documentation supports validation in biotechnological processes, further establishing the indispensability of magnetic mixers in ensuring precision, control, and efficiency in the field of biotechnology.

Seamless Integration of Magnetic Mixers in Biotechnological Settings

The seamless integration of magnetic mixers in biotechnological settings spans from lab-scale operations to large-scale industrial processes, showcasing their versatility and utility. In laboratory settings, these mixers play a pivotal role in microfluidic devices, facilitating applications in microreactors, concentration gradient generators, micro-heat exchangers, and lab-on-a-chip devices. Their precise control over magnetic force values makes them particularly well-suited for these intricate applications. Transitioning to industrial applications, magnetic mixers prove invaluable in large-scale stirred vessels, renowned for their easy installation, reduced power requirements, and efficacy in handling viscous fermentations. Industry leaders like Alfa Laval are extending their magnetic mixer offerings, exemplified by products like the LeviMag UltraPure, tailored for the sterile production of biotechnological and pharmaceutical products. Beyond operational efficiency, magnetic mixers contribute to environmental sustainability by leveraging electromagnetic fields to control various biotechnological processes without compromising the characteristics of cultivation mediums or final products. The widespread adoption of magnetic mixers underscores their significance, providing precise control and sustainability benefits in both laboratory and industrial biotechnological processes.

How Do Magnetic Coupled Mixers Enhance Efficiency and Productivity in Biotech Applications?

Magnetic coupled mixers play a pivotal role in elevating efficiency and productivity within biotech applications. Their efficient mixing capabilities, characterized by strong vortexes and low-speed agitation, operate across a broad speed spectrum, ensuring precise control over the mixing process. Featuring a specially designed four-wing impeller, these mixers not only deliver high pumping efficiency for safeguarding product integrity but also facilitate thorough mixing down to the last drop. Their easy cleaning and maintenance attributes, coupled with their integration capabilities with automated systems, make them a preferred choice for pharmaceutical manufacturers aiming to enhance operational processes. The promotion of 100% yield and the reduction of contamination risk by eliminating the need for a shaft seal further solidify the role of magnetic coupled mixers in improving reliability and operational excellence within biotech processes. Magnetic coupled mixers stand as a valuable asset in the biotechnology domain, ensuring efficient mixing, ease of maintenance, enhanced productivity, and reduced contamination risk.

The Magnetic Connection and Its Significance in Ensuring Contamination-Free Processes

The magnetic connection in mixers serves as a crucial element in guaranteeing contamination-free processes within the realm of biotechnology. Operating on the principle of a hermetically sealed design, magnetic mixers transmit the driving force without direct contact, utilizing magnetic fields to ensure complete containment and isolation, thereby eliminating the risk of contamination. This contactless design proves especially advantageous for hygienic and sterile applications, making it an ideal solution for demanding biotechnological processes. The simplicity inherent in magnetic stirrers facilitates ease of cleaning and contamination control, with only two main parts involved: the mixing bar and the sample container. The stirring bars used in magnetic mixers are FDA-approved and feature coatings that prevent the processed media from coming into contact with the magnet, further reducing the risk of contamination. The magnetic coupling mechanism, achieved through two sets of strong magnets, ensures a contamination-free mixing process by maintaining separation between the impeller inside the tank and the rotor outside the tank. The magnetic connection in mixers is paramount for fostering contamination-free processes in biotechnology, offering a combination of a hermetically sealed design, simplicity in cleaning, FDA-approved stirring bars, and a unique magnetic coupling mechanism for a safer and more efficient mixing process.


Magnetic coupled mixers have revolutionised the landscape of biotechnology by providing efficient, reliable, and contamination-free mixing solutions. Their working principle, driven by a rotating magnetic field, ensures precise control over stirring processes, making them indispensable in the pharmaceutical and biotech industries. The unique features of magnetic mixers, including their adaptability, precision, and ease of maintenance, contribute to operational excellence and cost efficiency. From laboratory applications in microfluidic devices to large-scale industrial processes, magnetic mixers seamlessly integrate into diverse biotechnological settings. Their significance is further underscored by the safety-first approach, which leverages magnetic connections to eliminate the risk of contamination and ensure the integrity of sterile processes. As industry leaders continue to enhance and expand their magnetic mixer offerings, these innovative solutions will likely remain at the forefront of advancements in biotech applications, setting new standards for efficiency, productivity, and safety in the field.